ANSWER: The Bible does not imply or teach that the upstairs room had any special importance or significance to Christ! In New Testament times, most of the houses in Jerusalem had an upper room which was customarily designated as a place set aside for conversation, for devotions, and often for placing of the dead prior to burial. Christ and the apostles used an upper room simply because of custom and availability. The word translated as “upper room” occurs four times in the new Testament; in the two places mentioned in the question (Luke 22:12 & Acts 1:13); in Acts 9:37-38, where the body of Dorcas was laid; and in Acts 20:8, “And there were many lights in the upper chamber.” If one would assume from these passages that the Lord’s Supper could be taken only in an upper room, then he or she would also have to assume that when we die, our bodies could only be laid in an upper room, and that we could have lights only in an upper room! Surely, such is not the case! Further, if the position suggested in the question was adopted, how could one stop with the assumption that communion should be taken in just any upper room? Why would it not be necessary to assume that it should be taken only in the same upper room; the one that Christ used? Should it be taken in an upper room on the second floor or the third floor? Should we similarly assume that the Jordan River had some importance to Christ since He was baptized there? If so, should we not further assume that we also must be baptized in the Jordan or, at least, in some other river? Would this mean we could not be scripturally baptized in a lake, pool, bathtub, or baptistry? Surely not! The important thing clearly is the element of water (1 Peter 3:21), not the location of the water. So it is with the Lord’s Supper! The important things are the elements of unleavened bread and fruit of the vine (Matthew 26:26-29; 1 Corinthians 11:23-26), not the location of the service!